![]() This can lead to a wide range of neuropsychiatric symptoms, from fatigue and confusion to coma. Neurologic: Hypercalcemia causes cells to become refractory to stimulation due to hyperpolarization of cell membranes. Conversely, acute mild hypercalcemia in the 11.0 to 11.5 mg/dL range may also cause symptoms, for example in an elderly patient who is taking sedative medications. Generally people with serum calcium levels above 13 mg/dL are symptomatic, though some patients with a very gradual rise in serum calcium levels may remain asymptomatic even with calcium levels above 15 mg/dL. Age, comorbidities, rate of rise, and concurrent medication use affect presenting symptoms. ![]() The development of symptoms depends on the degree and duration of hypercalcemia. Are You Sure the Patient Has Malignancy-Associated Hypercalcemia (MAHC)? Symptoms and signs
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